Ginkgo Biloba Extract Powder Flavone Glycosides

The Ginkgo biloba herb is used in the traditional Chinese medicine system to treat many different disorders. Recently Ginkgo biloba extract attract researchers because of its wide range of medicinal properties. Multiple research studies, including human trial results, were performed to check the efficacy of Ginkgo biloba extract on brain dysfunction, cardiovascular diseases, carcinogen metabolism, and some sensorial tissue age-associated diseases. Ginkgo biloba extract is available as an over-the-counter (OTC) product. Ginkgo biloba extract is considered safe when the products take under the healthcare professionals’ management. Healthcare professionals can identify the risk-benefit ratio by assessing the individual patient’s perspective. 
What is Ginkgo Biloba extract?
Ginkgo biloba extract is extracted from the leaves of the Ginkgo biloba tree. Standardized Ginkgo biloba extract contains a variety of flavone glycosides and terpenoids. Ginkgo biloba extract is also known as Ginkgo extract, Ginkgo Biloba leaf powder, etc. 
Constituents of Ginkgo Biloba
Ginkgo biloba extract containing major phytochemicals are terpenoids, flavonol glycosides, and proanthocyanidins. The combination of these phytochemicals exerts pharmacological properties. A significant amount of flavonol glycosides like quercetin and catechin are present in the extract. Ginkgolides and bilobalide are two unique types of terpenoids are present in Ginkgo biloba extract. The detailed evaluation of chemical constituents of Ginkgo biloba extract is as follows: flavone glycosides (22%–27%), Ginkgolide A, B, and C (2.8%–3.4%), bilobalide (2.6%–3.2%), and ginkgolic acid (less than five ppm).
Terpene lactones
Terpene lactones are a group of compounds with distinctive chemical structures. Ginkgo biloba extract is the primary source of terpene lactones. Ginkgo biloba extract contains 6%–7% terpene lactones. Ginkgolides and bilobalide are two terpene lactones. Both of these Terpene lactones present in Ginkgo biloba extract are responsible for the neuro-pharmacological activity. The Cmax of total ginkgolides and bilobalide are about two- to threefold higher when administered by the phospholipid complex. Ginkgo biloba extract containing ginkgolides has different forms like ginkgolides A, B, C, etc. Terpene lactones are widely used as an additive therapy in patients with ischemic cardiovascular and cerebrovascular diseases.
The CAS Number of terpene lactones is 33570-04-6. The molecular Formula of terpene lactones is C15 H18 O8. The Molecular Weight of terpene lactones is 326.30.
 
Ginkgo flavone glycosides
Ginkgo flavanoid glycosides are mono-, di- and tri-sugar units of quercetin, kaempferol and isorhamnetin. Ginkgo biloba extract contains 24% of Ginkgo flavonoid glycosides. The CAS number of Ginkgo biloba extract is 90045-36-6. Quercetin’s molecular weight is 302.23, and its CAS number is 117-39-5. The molecular weight of kaempferol is 286.24, and the CAS number is 520-18-3.
 The molecular weight of isorhamnetin is 316.26, and the CAS number is 480-19-3. Quercetin is very soluble in ether, methanol and soluble in ethanol, acetone, pyridine, and acetic acid. Quercetin is yellow. Kaempferol is insoluble in benzene; slightly soluble in chloroform; soluble in acetic acid, alkalies; very soluble in ethanol, ethyl ether, and acetone. Kaempferol is also yellow. Isorhamnetin is hydrophobic in nature and insoluble in water, and relatively neutral. But isorhamnetin is soluble in acetone, methanol, ethyl acetate, or DMSO.
Ginkgo Biloba extract forms and specifications
In general, Ginkgo biloba extract has a specification of 24% ginkgo flavone glycosides and 6% terpene lactones. But apart from this, the application of HPLC can isolate only lactones and form Ginkgo biloba extract with 24.0% flavones and 6.0% lactones. Other specific Ginkgo biloba extract forms are USP40 24/6 Ginkgo Acid<1ppm and EP9.0 24/6 Ginkgo Acid<1ppm. The custom standardized extract is also possible depending upon specifications.  
How does Ginkgo Biloba extract work?
Ginkgo biloba extract mediates therapeutic benefits by exerting peripheral and central effects. Research studies found that Ginkgo biloba extract acts as a vasodilator, metabolic, antiplatelet, antioxidant, and receptor/transmitter modulator.
Ginkgo Biloba extract Manufacturing Process
Raw materials used in the Ginkgo biloba extract manufacturing process are Ginkgo biloba leaves and aqueous ketone solvent. In the first step of Ginkgo biloba extract manufacturing, Ginkgo biloba leaves are ground for a better extraction process. Bioflavonoids and hydrophobic substances are first precipitated in the extraction liquors. Then, aqueous concentrate is filtered out. The filtrate is alkalinized to precipitate the proanthocyanidins. A further step is followed to eliminate the insoluble element comprising the proanthocyanidins through the filtration process. Then acidification of the filtrate is performed, followed by liquid-liquid extraction of the filtrate with a ketone in the presence of ammonium sulfate. Recovery of the extract is obtained by taking the ketone phase to dryness.
Ginkgo biloba Benefits
The bioactive phytochemicals like flavonoids and terpenoids present in Ginkgo biloba extract have the antioxidant and antiasthmatic property that provides multiple benefits like bronchospasm relief, skin regenerating, and wound-healing activities. Ginkgo biloba extract has various therapeutic benefits like improving blood circulation, preventing clot formation, enhancing flexibility in the blood capillary wall, and preventing neuroprotection from the oxygen-deprived condition. The significant therapeutic benefits of Ginkgo biloba extract are effective against Alzheimer’s disease, concentration deficit disorder, concentration difficulties, memory impairment, dementia cerebral insufficiency, and intermittent claudication. All these therapeutic benefits of Ginkgo biloba extract are effective for relieving pain and cramps in the legs induced by obstruction of the arteries. This herbal extract also controls vertigo and tinnitus, which usually causes hearing loss.
Ginkgo biloba memory
Ginkgo biloba extract has improved memory disorders associated with Alzheimer’s disease and dementia by activating the cholinergic system. Ginkgo Biloba extract can alter steady-state visually evoked potential and imparts working memory improvements.
Ginkgo biloba tinnitus
Tinnitus is an ear disease associated with several physical and mental disorders. In some cases, Ginkgo biloba extract improves tinnitus. [24] Ginkgo biloba extract improves vestibulo-ocular motor and vestibulo-spinal compensation.
Ginkgo biloba for vertigo
Ginkgo biloba extract can alleviate vertigo in elderly patients by relieving concomitant neurosensory symptoms. Researchers also reported that Ginkgo biloba extract has efficacy in vertigo treatment.
Supports Healthy Brain Function
Ginkgo biloba extract containing phytochemicals like flavonoids deactivate damaging oxygen free radicals, and terpenoids exert a neuroprotective effect in the brain by antagonizing platelet-activating factors. Combination of these pharmacological activities, Ginkgo biloba extract, may improve memory and learning ability. Ginkgo biloba extract promotes blood flow in the microcirculation, hypoxia tolerance in brain cells, and blood viscosity due to its antioxidant, anti-inflammatory, and other activities.
Mental Alertness, Concentration, and Focus
Ginkgo biloba extract effectively affects cognitive performance and mental condition in patients with Alzheimer’s disease and mild dementia. The clinical efficacy of Ginkgo biloba extract is comparable with donepezil. 
 Ginkgo biloba extract supplement improves alertness and mental performance. Ginkgo biloba extract has been used therapeutically for many years for symptoms such as memory deterioration, cognitive decline, and decreased alertness.
Ginkgo Biloba extract side effects
Ginkgo biloba extract is generally considered safe, and no evidential adverse drug interactions have been reported yet. In rare cases, some patients may have headaches, sleep disturbance or dizziness, skin reactions, and mild gastrointestinal upset. 
However, precautionary measures should be taken in the case of a patient under other MAO-inhibitor drugs. Ginkgo biloba extract may give a synergistic effect with prescribed MAO-inhibitors other medicines. Moreover, caution should be taken in the case of concomitant administration of Ginkgo biloba extract with anticoagulants because of the antiplatelet activity of Ginkgo biloba extract.
Ginkgo Biloba extract dosage
The dosage of Ginkgo biloba extract is 240 mg/day or more to achieve a better therapeutic effect. However, clinical consultation is recommended for effective treatment outcomes.
Where to buy bulk Ginkgo Biloba extract powder
Luckherb is a one roof solution as it is a manufacturing and supplier of different natural ingredients essential for health. Luckherb has an R&D and quality control department along with a manufacturing unit. Lukeherb introduces authentic Ginkgo biloba extract. China is the native place of Ginkgo biloba. Luke herb is a China-based Ginkgo biloba extract manufactured in Lukeherb and is a pure and genuine source for bulk purchase. Buyers can send an email to Lukeherb for a quotation.